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Malarial nephropathy
Malarial nephropathy is renal failure attributed to malarial infection. Among various complications due to infection, renal-related disorders are often the most life-threatening.〔Barsoum, Rashad S. “Malarial Acute Renal Failure.” J Am Soc Nephrol 11 (2000): 2147-2154.〕 Including malaria-induced renal lesions, infection may lead to both tubulointerstitial damage and glomerulonephritis.〔Das, B.S. “Renal failure in malaria.” J Vector Borne Dis. 45 (2008): 83-97.〕 In addition, malarial acute renal failure has emerged as a serious problem due to its high mortality rate in non-immune adult patients.〔〔Manan, Junejo Abdul, Hassan Ali, and Manohar Lal. “Acute Renal Failure Associated with Malaria.” J Ayub Med Coll Abbottabad 4 (2006): 47-52.〕
==Suffering areas==
Malarial nephropathies are reported in endemic areas, such as Southeast Asia, India, and Sub-Saharan Africa.〔〔〔 The pathogenesis of acute renal failure in severe malaria is unspecific and multifactorial—it affects fewer than 4.8 percent of cases, but reports a high risk of mortality (15 to 45 percent).〔〔〔 Histologic evidence shows a large combination of pathogenic mechanisms at play—acute tubular necrosis, interstitial nephritis and glomerulonephritis.〔 Risk factors for malarial acute renal failure include delayed diagnosis, high parasitemia, and clinical presentation of oliguria, low blood pressure, severe anemia, and jaundice. In addition, patients already suffering from diarrhea, hepatitis, or respiratory distress have a worse prognosis.〔〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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